Tariq Haider RG Pharmaceutica
made the medicine L-Methylfolate with the
name of MyFol 400 Folate is a general term that refers to compounds not only
structurally but also with activity similar to that of folic acid. Folic
acid (2-amino-4-hydroxy-6-metilenoaminobenzoil-glutamic acid), also known as
pteroylglutamic acid, vitamin B9 and vitamin F, is naturally present in foods,
generally, in reduced form, such as polyglutamates derivatives with 2 to 7
glutamic acid residues known as folates. To be used by our body folic acid
must be converted to its active form - 5-MTHF.
High levels of homocysteine involve the cardiovascular
system disorders including thrombosis, stroke, atherosclerosis and myocardial
infarction. 5-MTHF in addition to reducing the levels of homocysteine in
the blood, also enhances blood flow in peripheral arteries, thus increasing
nitric oxide (NO) in the vascular endothelium. Most risk factors for
atherosclerosis are associated with deficiency in vasodilation due to
insufficient production of NO (chronic exposure of vascular endothelial cells
to homocysteine compromises the proper production of NO), this leads to
endothelial injury and the onset of atherosclerosis, including increased
adhesion of monocytes and platelets, increased smooth muscle proliferation and
thrombus formation. 5-MTHF enhances synthesis.
Reduction of homocysteine plasma levels, thereby
increasing the availability of endothelial cofactors such as
tetrahydrobiopterin;
